Homer 1a Suppresses Neocortex Long-Term Depression in a Cortical Layer-Specific Manner

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Homer 1a suppresses neocortex long-term depression in a cortical layer-specific manner.

Homer1a/Vesl-1S is an activity-dependently induced member of the scaffold protein family Homer/Vesl, which is known to link group I metabotropic glutamate receptors (mGluRs) to endoplasmic calcium release channels and to regulate them. Here we studied roles of Homer 1a in inducing long-term depression (LTD) in rat visual cortex slices. Homer 1a protein was injected by diffusion from whole cell ...

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ژورنال

عنوان ژورنال: Journal of Neurophysiology

سال: 2008

ISSN: 0022-3077,1522-1598

DOI: 10.1152/jn.01101.2007